Description
People use andarine to improve athletic performance and for conditions such as involuntary weight loss in people who are very ill (cachexia or wasting syndrome), osteoporosis, and prostate health. Andarine attaches to proteins in the body known as androgen receptors. When andarine binds to these receptors, it tells the muscles and bones in the body to grow. Unlike some other chemicals that bind to androgen receptors, such as steroids, andarine doesn’t seem to cause as many side effects in other parts of the body. Unlike anabolic steroids, which bind to androgen receptors in many tissues all over the body, individual SARMs selectively bind to androgen receptors in certain tissues, but not in others. Nonetheless, they are still exhibit androgenic and anabolic effects. SARMS are not anabolic steroids; rather, they are synthetic ligands that bind to androgen receptors. Depending on their molecular structure, they act as agonists, partial agonists, and antagonists. It is thus in a selective manner, that SARMS modulate or mediate coregulators and transcription factors or signaling cascade proteins to promote anabolic activity. Studies have shown S-4 is a full androgen receptor agonist in muscle tissue, and a partial agonist in the prostate, making it an ideal candidate as an alternative to steroidal androgen receptor agonists (i.e., testosterone and DHT), due to associated adverse effects on liver, heart, and fertility. The selective binding effects of S-4, and it high androgen binding affinity, can increase muscle tissue and size. S-4 treatment caused a significantly larger increase in total body bone mineral density than DHT. Consequently, this can protect against bone less in elderly populations.
